Professor of Surgery and Chief,
Section of Vascular Surgery
5841 S. Maryland Avenue,
MC 5028, J-555
Chicago, IL 60637
Phone: 773-702-6128
Fax: 773-702-0863
E-mail:
Education
Mb. Bch. Diploma, Cairo University, School of Medicine, 1977
Transitional Internship, Cairo University Hospitals, 197-78
Institute for Cardiothoracic Surgery, Cairo, Egypt, 1978 - 79
General Practitioner, Military Service, Egypt, 1979 - 80
Surgical Internship, Linz General Hospital, Linz, Austria, 1980 - 81
Surgical Internship, Maryland General Hospital, Baltimore, MD, 1981 -
82
General Surgical Residency, Henry Ford Hospital, Detroit, MI, 1982 - 86
Clinical Vascular Fellow, Henry Ford Hospital, Detroit, MI, 1986 - 87
Cardiovascular Post- Doctoral Research Fellow, University of Chicago,
1987 – 89
• Clinical
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Research in our lab focuses primarily the mechanisms behind the development of a variety of vasculopathies as well as the development of new and better treatment modalities. Our sponsored research projects have included examinations of various pathobiologic and biomechanical mechanisms in arterial and venous intimal hyperplasia, and treatment of arterial and venous intimal hyperplasia. Current research focuses on the biomechanics of intimal hyperplasia and the imaging and molecular determinants of carotid atherosclerotic plaque vulnerability. Additionally, we actively participate in many clinical trials (drug and device) involving the treatment of a variety of vascular disease processes.
An evaluation of the effects of biomechanical factors such as flow rate, turbulence, and geometry in relation to arteriovenous grafts (in particular polytetrafluoroethylene "PTFE" femoral artery to vein interposition grafts).
Venous anastomotic intimal hyperplasia (VAIH) is the most prevalent cause of hemodialysis arteriovenous (AV) graft failure. The economic impact of AV access and its related morbidity approaches one billion dollars annually in the US. Previously, we have demonstrated that hemodynamic forces regulate key in vivo molecular and structural events in artery wall intimal hyperplasia. We will apply and extend this expertise to investigate the independent role(s) of turbulence-induced solid and fluid dynamic forces in inducing VAIH following AV graft implantation utilizing a realistic experimental in vivo model of the human arteriovenous circuit and VAIH. This project hopes to further elucidate: the patterns and roles of turbulence-induced vein wall vibration in VAIH; the effects of vein wall vibrations on the activity of extracellular protein kinases required for the transcriptional activation of a variety of genes involved in vascular smooth muscle differentiation, proliferation, apoptosis and VAIH.
Discovery of imaging and biologic markers to detect & monitor atherosclerosis plaque vulnerability is critical for identification of unstable vulnerable plaques in asymptomatic and symptomatic patient for future atherosclerotic plaque stabilization drug development. Since there is no golden standard plaque rupture animal model available, human athero-plaque is the only reliable tissue resource that can be used for biomarker/new target studies. Carotid plaque tissues are collected from patients undergoing carotid endarterectomy with the goal of identifying genes and/or proteins which are expressed differentially in stable and unstable plaques.
Lee SW, Smith DS, Loth F, Fischer PF, Bassiouny HS. Importance of flow division on transition to turbulence within an arteriovenous graft. J Biomech 2007; 40(5):981-92 (PubMed)
Wahlgren CM, Piano G, Desai TR, Shaalan W, Bassiouny HS. Transperitoneal versus retroperitoneal suprarenal cross-clamping for repair of AAA with a hostile infrarenal aortic neck. Annals of Vascular Surgery 2007; 21(6):687-694 (PubMed)
Desai TR, Bassiouny HS. Diagnosis and treatment of non-occlusive mesenteric ischemia. In: RB Rutherford, eds. Vascular Surgery. 6th ed. New York, NY: Elsevier; 2005:1728-1731
Lee SW, Loth F, Royston TJ, Fischer PF, Grogan JK, Bassiouny HS. Flow induced vein wall vibration in an arteriovenous graft. Journal of Fluids and Structures 2005; 20(6):837-852
Arslan N, Loth F, Bertram CD, Bassiouny HS. Transitional flow field characterization inside an arteriovenous graft-to-vein anastomosis under pulsatile flow conditions. European Journal of Mechanics 2005; 24(3):353-365
Grogan J, Castilla M, Lozanski L, Griffin A, Loth F, Bassiouny H. Frequency of critical stenosis in primary arteriovenous fistulae before hemodialysis access: should duplex ultrasound surveillance be the standard of care? J Vasc Surg 2005; 41(6):1000-6 (PubMed)
Grogan JK, Shaalan WE, Cheng H, Gewertz B, Desai T, Schwarze G, Glagov S, Lozanski L, Griffin A, Castilla M, Bassiouny HS. B-mode ultrasonographic characterization of carotid atherosclerotic plaques in symptomatic and asymptomatic patients. J Vasc Surg 2005; 42(3):435-41 (PubMed)
Pearce BJ, Baldwin Z, Bassiouny H, Gewertz BL, McKinsey JF. Endovascular solutions to complications of open aortic repair. Vasc Endovascular Surg 2005; 39(3):221-8 (PubMed)
Yazicioglu Y, Royston TJ, Spohnholtz T, Martin B, Loth F, Bassiouny HS. Acoustic radiation from a fluid-filled, subsurface vascular tube with internal turbulent flow due to a constriction. J Acoust Soc Am 2005; 118(2):1193-209 (PubMed)
Baldwin ZK, Pearce BJ, Curi MA, Desai TR, McKinsey JF, Bassiouny HS, Katz D, Gewertz BL, Schwartz LB. Limb salvage after infrainguinal bypass graft failure. J Vasc Surg 2004; 39(5):951-7 (PubMed)
Shaalan WE, Cheng H, Gewertz B, McKinsey JF, Schwartz LB, Katz D, Cao D, Desai T, Glagov S, Bassiouny HS. Degree of carotid plaque calcification in relation to symptomatic outcome and plaque inflammation. J Vasc Surg 2004; 40(2):262-9 (PubMed)
Rossi PJ, Skelly CL, Meyerson SL, Bassiouny HS, Katz D, Schwartz LB, McKinsey JF, Gewertz BL, Desai TR. Redo infrainguinal bypass: factors predicting patency and limb salvage. Ann Vasc Surg 2003; 17(5):492-502 (PubMed)
Shaalan WE, French-Sherry E, Castilla M, Lozanski L, Bassiouny HS. Reliability of common femoral artery hemodynamics in assessing the severity of aortoiliac inflow disease. J Vasc Surg 2003; 37(5):960-9 (PubMed)
Curi MA, Skelly CL, Baldwin ZK, Woo DH, Baron JM, Desai TR, Katz D, McKinsey JF, Bassiouny HS, Gewertz BL, Schwartz LB. Long-term outcome of infrainguinal bypass grafting in patients with serologically proven hypercoagulability. J Vasc Surg 2003; 37(2):301-6 (PubMed)
Loth F, Fischer PF, Arslan N, Bertram CD, Lee SE, Royston TJ, Shaalan WE, Bassiouny HS. Transitional flow at the venous anastomosis of an arteriovenous graft: potential activation of the ERK1/2 mechanotransduction pathway. J Biomech Eng 2003; 125(1):49-61 (PubMed)
Bassiouny HS, Zarins CK, Lee DC, Skelly CL, Fortunato JE, Glagov S. Diurnal heart rate reactivity: a predictor of severity of experimental coronary and carotid atherosclerosis. J Cardiovasc Risk 2002; 9(6):331-8 (PubMed)
Loth F, Jones SA, Zarins CK, Giddens DP, Nassar RF, Glagov S, Bassiouny HS. Relative contribution of wall shear stress and injury in experimental intimal thickening at PTFE end-to-side arterial anastomoses. J Biomech Eng 2002; 124(1):44-51 (PubMed)
MacKenzie KS, French-Sherry E, Burns K, Pooley T, Bassiouny HS. B-mode ultrasound measurement of carotid bifurcation stenoses: is it reliable? Vasc Endovascular Surg 2002; 36(2):123-35 (PubMed)
Kilpatrick D, Goudet C, Sakaguchi Y, Bassiouny HS, Glagov S, Vito R. Effect of plaque composition on fibrous cap stress in carotid endarterectomy specimens. J Biomech Eng 2001; 123(6):635-8 (PubMed)
Song RH, Kocharyan HK, Fortunato JE, Glagov S, Bassiouny HS. Increased flow and shear stress enhance in vivo transforming growth factor-beta1 after experimental arterial injury. Arterioscler Thromb Vasc Biol 2000; 20(4):923-30 (PubMed)
Fortunato JE, Bassiouny HS, Song RH, Kocharian H, Glagov S, Edelstein C, Scanu AM. Apolipoprotein (a) fragments in relation to human carotid plaque instability. J Vasc Surg 2000; 32(3):555-63 (PubMed)
Fortunato JE, Mauceri HJ, Kocharyan H, Song RH, Salloum R, Vosicky J, Swedberg K, Malik S, Abusharif F, Glagov S, Weichselbaum RR, Bassiouny HS. Gene therapy enhances the antiproliferative effect of radiation in intimal hyperplasia. J Surg Res 2000; 89(2):155-62 (PubMed)
