Assistant Professor
Department of Surgery
Section of Vascular Surgery
J-555, MC 5028
5841 S. Maryland Avenue
Chicago, IL 60637
Phone: 773-702-6128
Email:
Education:
BS, Biochemistry, Trinity College, Hartford, CT, 1989-1993
MD, New York Medical College, Valhalla, NY, 1993-1997
Postdoctoral Training:
General Surgery Resident, The University of Chicago, 1997-2004
Research Fellow, The University of Chicago, 1999-2001
Vascular Surgery Fellow, Hospital of the University of Pennsylvania, Philadelphia,
PA, 2004-2005
• Clinical
Interests
• Complete
Bibliography
• Image Gallery:
(To view the images click on the icon below.)
Vein graft neointimal hyperplasia and failure.
Beta-galactosidase transgene expression (dark blue stain) in rabbit external jugular vein patches harvested four weeks after exposure to R849.
Approximately 60,000,000 Americans have cardiovascular disease, including one million Americans that are newly diagnosed with symptomatic peripheral vascular occlusive disease annually. Atherosclerotic disease in the periphery is exceedingly common, as it represents the natural senescence of arteries. The United States Census Bureau estimates that, by the year 2050, there will be eighty million Americans over the age of 65, representing literally millions of citizens requiring treatment. The economic and social cost of this disease is immense.
Although endovascular intervention may be appropriate for patients with short-segment non-occlusive lesions, there is no currently approved infrainguinal stent, and the only available treatment for long-segment arterial occlusion is bypass grafting. The majority of patients undergoing bypass grafting enjoy a favorable immediate operative result. However, the lifespan of the graft is highly variable and grafts fail in subsequent years at an alarming rate. For all vein grafts in all patients, the reported 4-year primary patency rate is only about 40% (fig. 1). The consequences of vein graft failure can be devastating, as nearly 60% of patients experiencing an episode of failure will require extremity amputation. Patients presenting with tissue loss as an indication for bypass grafting carry a particularly poor prognosis, as a full 83% will lose their limb if their graft fails.
Current research is directed towards creating and characterizing an animal model of graft failure that exhibits greater VSMC proliferation, aberrant vascular remodeling, and lesion development than traditional models, resulting in conduits that phenotypically resemble human restenosis. Vascular tissues will be exposed to genetically-engineered Herpes Simplex Virus-1 (HSV-1). Incorporation of HSV-1 should attenuate neointimal hyperplasia and prevent vascular proliferative disease. Future goals include designing, generating and testing an HSV-1 eluting intravascular stent.
A genetically engineered herpes simplex virus, primarily known for causing cold sores, may help keep arteries "free-flowing" in the weeks following angioplasty or stent placement for patients (Skelly CL, et al., PNAS USA. 2007 Jul 24;104(30):12474-8).
Woo EY, Karmacharya J, Velazquez OC, Carpenter JP, Skelly CL, Fairman RM. Differential effects of carotid artery stenting versus carotid endarterectomy on external carotid artery patency. J Endovasc Ther 2007; 14(2):208-13 (PubMed)
Skelly CL, Chandiwal A, Vosicky JE, Weichselbaum RR, Roizman B. Attenuated herpes simplex virus 1 blocks arterial apoptosis and intimal hyperplasia induced by balloon angioplasty and reduced blood flow. Proc Natl Acad Sci U S A 2007; 104(30):12474-8 (PubMed)
Wahlgren CM, Prema J, Spiguel LR, Skelly CL. Restenosis after carotid angioplasty and stent: a review Italian J Vasc Endovasc Surg 2007; 14:103-114
Skelly CL, Gallagher K, Fairman RM, Carpenter JP, Velazquez OC, Parmer SS, Woo EY. Risk factors for restenosis after carotid artery angioplasty and stenting. J Vasc Surg 2006; 44(5):1010-5 (PubMed)
Szeto WY, Fairman RM, Acker MA, Skelly CL, Augoustides JG, McGarvey M, Woo EY, Velazquez OC. Emergency endovascular deployment of stent graft in the ascending aorta for contained rupture of innominate artery pseudoaneurysm in a pediatric patient. Ann Thorac Surg 2006; 81(5):1872-5 (PubMed)
Parmer SS, Skelly CL, Carpenter JP. Ruptured popliteal artery aneurysm: a case report. Vasc Endovascular Surg 2006; 40(1):71-4 (PubMed)
Baldwin ZK, Chandiwal A, Balasubramanian V, Pearce BJ, Curi MA, Skelly CL, Huang WW, Vosicky JE, Roizman B, Weichselbaum RR, Schwartz LB. Modulation of vascular remodeling induced by a brief intraluminal exposure to the recombinant R7020 strain of Herpes simplex-1. J Vasc Surg 2005; 41(1):115-21 (PubMed)
Curi MA, Skelly CL, Meyerson SL, Baldwin ZK, Balasubramanian V, Advani SJ, Glagov S, Roizman B, Weichselbaum RR, Schwartz LB. Sustained inhibition of experimental neointimal hyperplasia with a genetically modified herpes simplex virus. J Vasc Surg 2003; 37(6):1294-300 (PubMed)
Curi MA, Skelly CL, Baldwin ZK, Woo DH, Baron JM, Desai TR, Katz D, McKinsey JF, Bassiouny HS, Gewertz BL, Schwartz LB. Long-term outcome of infrainguinal bypass grafting in patients with serologically proven hypercoagulability. J Vasc Surg 2003; 37(2):301-6 (PubMed)
Skelly CL, Jackson CC, Wu Y, Hill CB, Chwals WJ, Liu DC. Thoracoscopic thymectomy in children with myasthenia gravis. Am Surg 2003; 69(12):1087-9 (PubMed)
Rossi PJ, Skelly CL, Meyerson SL, Bassiouny HS, Katz D, Schwartz LB, McKinsey JF, Gewertz BL, Desai TR. Redo infrainguinal bypass: factors predicting patency and limb salvage. Ann Vasc Surg 2003; 17(5):492-502 (PubMed)
Bassiouny HS, Zarins CK, Lee DC, Skelly CL, Fortunato JE, Glagov S. Diurnal heart rate reactivity: a predictor of severity of experimental coronary and carotid atherosclerosis. J Cardiovasc Risk 2002; 9(6):331-8 (PubMed)
Curi MA, Skelly CL, Quint C, Meyerson SL, Farmer AJ, Shakur UM, Loth F, Schwartz LB. Longitudinal impedance is independent of outflow resistance. J Surg Res 2002; 108(2):191-7 (PubMed)
Curi MA, Skelly CL, Woo DH, Desai TR, Katz D, McKinsey JF, Bassiouny HS, Gewertz BL, Schwartz LB. Long-term results of infrageniculate bypass grafting using all-autogenous composite vein. Ann Vasc Surg 2002; 16(5):618-23 (PubMed)
Curi MA, Skelly CL, Meyerson SL, Baldwin ZK, Lee E, Lanahan J, Jayakar D, Bassiouny HS, Schwartz LB. Differential mechanical activation of mitogen-activated protein kinases in intact human blood vessels. J Surg Res 2002; 108(2):198-202 (PubMed)
Curi MA, Skelly CL, Meyerson SL, Woo DH, Desai TR, McKinsey JF, Bassiouny HS, Katz D, Gewertz BL, Schwartz LB. Conduit choice for above-knee femoropopliteal bypass grafting in patients with limb-threatening ischemia. Ann Vasc Surg 2002; 16(1):95-101 (PubMed)
Curi MA, Skelly CL, Woo DH, Desai TR, Winterfield R, Gewertz BL, Schwartz LB. Spontaneous perforation of a non-aneurysmal visceral aorta. Cardiovasc Surg 2002; 10(3):279-83 (PubMed)
Rossi PJ, Desai TR, Skelly CL, Curi MA, Glagov S, Schwartz LB. Paravisceral aortic thrombus as a source of peripheral embolization--report of three cases and review of the literature. J Vasc Surg 2002; 36(4):839-43 (PubMed)
Skelly CL, Farmer AJ, Curi MA, Meyerson SL, Davidovitch RS, Woo DH, Schwartz LB. Aortic reconstruction in patients with functioning renal allografts. Ann Vasc Surg 2002; 16(6):779-83 (PubMed)
Skelly CL, Meyerson SL, Curi MA, Desai TR, Bassiouny HS, McKinsey JF, Gewertz BL, Schwartz LB. Routine early postoperative duplex scanning is unnecessary following uncomplicated carotid endarterectomy. Vasc Endovascular Surg 2002; 36(2):115-22 (PubMed)
Skelly CL, Meyerson SL, Curi MA, Loth F, Schwartz LB. The hemodynamics of vein grafts: measurement and meaning. Ann Vasc Surg 2001; 15(1):110-22 (PubMed)
Skelly CL, Curi MA, Meyerson SL, Hari D, Vosicky J, Advani SJ, Mauceri H, Glagov S, Roizman B, Weichselbaum RR, Schwartz LB. Prevention of restenosis by Herpes simplex virus. Surg Forum 2001; 52:357-358 (PubMed)
Refai D, Meyerson SL, Skelly CL, Curi MA, Glagov S, Schwartz LB. Saphenous vein graft aneurysm associated with fibromuscular dysplasia. Surgical Rounds 2001; 24:344-355
Meyerson SL, Refai D, Skelly CL, Curi MA, Glagov S, Schwartz LB. Hemodynamically “insignificant” stenoses stimulate neointimal thickening in experimental vein grafts. International J Angiol 2001; 10:92-95
Desai TR, Meyerson SL, Skelly CL, MacKenzie KS, Bassiouny HS, Katz D, McKinsey JF, Gewertz BL, Schwartz LB. Patency and limb salvage after infrainguinal bypass with severely compromised ("blind") outflow. Arch Surg 2001; 136(6):635-42 (PubMed)
Meyerson SL, Skelly CL, Curi MA, Desai TR, Katz D, Bassiouny HS, McKinsey JF, Gewertz BL, Schwartz LB. Long-term results justify autogenous infrainguinal bypass grafting in patients with end-stage renal failure. J Vasc Surg 2001; 34(1):27-33 (PubMed)
Meyerson SL, Skelly CL, Curi MA, Shakur UM, Vosicky JE, Glagov S, Schwartz LB, Christen T, Gabbiani G. The effects of extremely low shear stress on cellular proliferation and neointimal thickening in the failing bypass graft. J Vasc Surg 2001; 34(1):90-7 (PubMed)
Moawad J, Meyerson SL, Refai D, Skelly CL, Leiden JM, Schwartz LB. Adenoviral-mediated gene transfer in human and animal vein grafts using clinically relevant exposure times, pressures, and viral concentrations. Ann Vasc Surg 2001; 15(3):367-73 (PubMed)
Skelly CL, Curi MA, Meyerson SL, Woo DH, Hari D, Vosicky JE, Advani SJ, Mauceri HJ, Glagov S, Roizman B, Weichselbaum RR, Schwartz LB. Prevention of restenosis by a herpes simplex virus mutant capable of controlled long-term expression in vascular tissue in vivo. Gene Ther 2001; 8(24):1840-6 (PubMed)
Meyerson SL, Skelly CL, Curi MA, Schwartz LB. Gene therapy for cardiovascular disease. Seminars in Cardiothoracic and Vascular Anesthesia 2000; 4(4):289-300
Meyerson SL, Shakur UM, Skelly CL, Loth F, McKinsey JF, Schwartz LB. The relationship between pre-operative duplex vein mapping and intraoperative longitudinal impedance in infrainguinal vein grafts. Vasc Surg 2000; 34(5):393-401
Meyerson SL, Moawad J, Loth F, Skelly CL, Bassiouny HS, McKinsey JF, Gewertz BL, Schwartz LB. Effective hemodynamic diameter: an intrinsic property of vein grafts with predictive value for patency. J Vasc Surg 2000; 31(5):910-7 (PubMed)
Baldwin ZK, Meyerson SL, Skelly CL, McKinsey JF, Bassiouny HS, MacDonald RL, Gewertz BL, Schwartz LB. Estimating the contemporary in-hospital costs of carotid endarterectomy. Ann Vasc Surg 2000; 14(3):210-5 (PubMed)
